The revolutionary STEM CELLs Therapy for KERATOCONUS: Eye to Eye # 2 with Prof. Dr. Jorge Alió
In this video Prof. Dr. Jorge Alió shares his insight about the current developments of stem cells therapy for keratoconus patients.
The interview involves a great explanation of how the damaged corneal structure can be recovered via cells therapy, the challenges and the revolutionary future of the stem cells therapy for corneal disorders.
SHORT NOTES :
00:00 / Introduction to Prof. Dr. Jorge Alió
00:49 / Presenting the main articles which will be discussed in the video
01:08 / Part I: What was the reason for starting stem cells (SCs) therapy for keratoconus patients
05:51 / A slide which shows the classification of groups with different SCs treatment modalities presented in the the studies
09:34 / Which SCs are showing more promising effect on human corneal tissue?
11:32 / Part II: What is the difference between decellularized and recellularized laminas
14:12 / Description of three different methods as a future treatment modalities based on the severity of corneal disorders
16:40 / What is the reason of highest keratocytes dencity in posterior stroma after decellularized donor lamina implantation?
18:56 / Part III: Could the SCs therapy be used in advanced cases (Hydrops) of keratoconus
22:37 / Could the SCs treatment be repeated?
24:37 / What would be the appropriate interval between the repeated procedures?
25:17 / Part IV: What is the biggest challenge for the future developmants of corneal SCs therapy?
The LIST of publications mentioned in the video:
00:51 / "Regenerative Surgery of the corneal stroma for advanced keratoconus: 1 - year outcomes" JL Alió, JL Alió del Barrio, M el Zarif et al. Am J Ophthalmol 2019;203:53-68
00:52 / "Corneal stroma cell density evolution in keratoconus corneas following the implantation of adipose mesenchymal stem cells and corneal laminas: an in vivo confocal microscopy study" M el Zarif, KA Jawad, JL Alió del Barrio, et al. Invest Ophthalmol Vis Sci 2020; 61(4):22
00:56 / "Corneal stromal regeneration: a review of human clinical studies in keratoconus treatment" M el Zarif, JL Alió, JL Alió del Barrio, et al. Front.Med 2021
01:37 / "Corneal graft failure: an update" JL Alió, A Montesel, F El Sayyad et al. Br J Ophthalmol.2021; 105(8)
01:45 / "Causes of corneal transplant failure: a multicentric study" A Gómez-Benlloch, A Montesel, L Pareja-Aricò et al. Acta Ophthalmol 2021;99(6)
09:43 / "Corneal Regeneration: Therapy and Surgery", Book. J. JL Alió, 2019
12:32 / "Corneal Stroma Cell Density Evolution in Keratoconus Corneas Following the Implantation of Adipose Mesenchymal Stem Cells and Corneal Laminas: An In Vivo Confocal Microscopy Study " M El Zarif, KA Jawad, JL. Alió Del Barrio et al. Investigative Ophthalmology & Visual Science April 2020, Vol.61, 22
20:33 / "Customized Stromal Lenticule Implantation for Keratoconus" F Doroodgar, M Jabbarvand, S Niazi. J Refract Surg 2020;36(12):786-794
22:11 / "In Vivo Confocal Microscopy of Stromal Lenticule Addition Keratoplasty for Advanced Keratoconus" L Mastropasqua, N Salgari, E D'Ugo, et al. J Refract Surg. 2020;36(8):544-550